Sudden cardiac arrest (SCA) remains one of the leading causes of mortality worldwide. Unlike a myocardial infarction (heart attack), which is caused by blocked coronary arteries, sudden cardiac arrest is an abrupt loss of heart function due to electrical instability, often occurring without warning.
The image above highlights a holistic classification of SCA causes, divided into three major categories:
This blog post breaks down each of these components in detail, making it easier for clinicians, students, and the public to understand the pathophysiology behind SCA.
🟥 1. Primary Ischemic Causes
Ischemia—lack of oxygenated blood—remains the most common trigger of sudden cardiac arrest. Any interruption in coronary blood flow can lead to ventricular arrhythmias such as ventricular tachycardia (VT) or ventricular fibrillation (VF).
1. Atherosclerotic Coronary Artery Disease (CAD)
The most frequent cause of SCA worldwide. Plaques can rupture, causing thrombosis and severe ischemia. Even before complete occlusion, plaque instability can lead to fatal arrhythmias.
2. Coronary Artery Embolism
Blood clots, valve vegetations, or debris may obstruct coronary arteries. These events are less common but often dramatic, rapidly compromising myocardial perfusion.
3. Spontaneous Coronary Artery Dissection (SCAD)
Seen more often in young women, especially postpartum. A tear in the arterial wall restricts blood flow and may lead to fatal arrhythmias.
4. Coronary Artery Spasm (Prinzmetal’s Angina)
Intense vasospasm can momentarily stop blood flow, triggering life-threatening arrhythmias even in individuals with no structural coronary disease.
5. Anomalous Origin of Coronary Artery
Congenital variations, especially arteries arising between the aorta and pulmonary artery, can be compressed during exertion, causing ischemia and SCA—particularly in young athletes.
🟩 2. Primary Structural Causes
Structural abnormalities change the heart’s anatomy, affecting its ability to pump effectively and maintain normal electrical conduction.
1. Hypertrophic Cardiomyopathy (HCM)
A leading cause of SCA in young individuals. Septal thickening creates an arrhythmogenic substrate, especially during exercise.
2. Dilated Cardiomyopathy
Ventricular enlargement leads to poor contractility and increased risk of sustained VT or VF.
3. Aortic Stenosis
Severe obstruction to left ventricular outflow raises wall stress and oxygen demand, predisposing the heart to sudden arrhythmias.
4. Congenital Heart Disease
Even after surgical repair, patients may retain scar tissue or abnormal conduction pathways that predispose them to SCA.
5. Pulmonary Embolism
A massive PE can trigger acute right ventricular failure and pulseless electrical activity (PEA).
6. Pericardial Tamponade
Fluid accumulation in the pericardial sac restricts cardiac filling, leading to collapse of cardiac output and arrest.
7. Arrhythmogenic Right Ventricular Dysplasia (ARVD / ARVC)
A genetic disorder where the right ventricle is replaced by fatty and fibrous tissue. Causes malignant arrhythmias, especially in young athletes.
🟦 3. Primary Electrical Causes
Electrical disorders disrupt the heart’s rhythm without necessarily affecting its structure.
1. Electrolyte Abnormalities
2. Drug Toxicities
Examples include:
Digoxin toxicity
These drugs alter conduction, repolarization, and may cause fatal arrhythmias.
3. Idiopathic Ventricular Tachycardia
Originates without identifiable structural or ischemic causes. Although sometimes benign, it can degenerate into VF.
4. Long QT Syndrome
Inherited or drug-induced. Prolonged repolarization increases risk of torsades de pointes and sudden death.
5. Brugada Syndrome
Genetic sodium channel disorder commonly presenting with ST-segment elevation in V1–V3. A major cause of SCA in Southeast Asian men.
6. Conduction Abnormalities
Advanced AV block or bundle branch block can lead to bradyarrhythmias and pulseless arrest.
7. Pre-excitation Syndromes (e.g., WPW)
Accessory pathways allow rapid conduction, leading to re-entrant tachyarrhythmias that may deteriorate into VF.
8. Commotio Cordis
Blunt chest trauma at a critical moment in the cardiac cycle triggers VF. Often seen in sports such as baseball or martial arts.
🟨 The Central Message: Rapid CPR Saves Lives
In the centre of the image is a reminder of the most critical step in cardiac arrest management:
Immediate, high-quality CPR.
Regardless of the underlying cause, early:
Chest compressions
Defibrillation (when appropriate)
Advanced cardiac life support (ACLS)
dramatically improves survival chances.
🫀 Why This Knowledge Matters in the Cath Lab
As Cath Lab professionals and emergency care providers, understanding these causes helps in:
✔ Rapid identification of ischemic vs non-ischemic etiologies
✔ Preparing appropriate interventional strategies
✔ Recognizing high-risk patients before they arrest
✔ Improving team readiness and ACLS response
SCA is not always caused by coronary occlusion. A broad differential saves lives.
References (Legitimate Medical Literature)
Al-Khatib SM, Stevenson WG, Ackerman MJ, et al. 2018 AHA/ACC/HRS Guideline for the Evaluation and Management of Patients With Cardiac Arrhythmias. Circulation.
Myerburg RJ, Junttila MJ. Sudden Cardiac Death Caused by Coronary Heart Disease. Circulation.
Maron BJ, Maron MS. Hypertrophic Cardiomyopathy. Lancet.
Priori SG, Blomström-Lundqvist C, et al. ESC Guidelines for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death.
Virani SS et al. Heart Disease and Stroke Statistics—American Heart Association 2023 Update.
Sommariva E, Brugada R. Brugada Syndrome: Genetic and Clinical Insights.
Hayes BD, et al. Toxicologic Causes of Cardiac Arrest. Emerg Med Clin North Am.